Package files: . mll.jar - programs only . mllwithdata.jar - both programs and data Installation: . Unpackage all files into an empty base directory: jar -xvf mll.jar OR jar -xvf mllwithdata.jar . The packages require Apache Ant (http://ant.apache.org/) and the Contrib tasks (http://sourceforge.net/projects/ant-contrib) to run. Install them if not already installed in your system. To run (with data): At the base directory, run the ant task "run": ant run Data files required for running the programs: data/ppi/ready/proteins.txt: list of protein names, one protein per line data/ppi/ready/proteinKernel.txt: protein kernel in tab-delimited format data/ppi/ready/goldPosProteinPairs.txt: tab-delimited gold-standard positive protein pairs, one pair per line data/ppi/ready/goldNegProteinPairs.txt: tab-delimited gold-sntadard negative protein pairs, one pair per line data/ddi/ready/domains.txt: list of domain instances, one instance per line, in format data/ddi/ready/domainKernel.txt: domain instance kernel in tab-delimited format data/ddi/ready/MediatingKernel.txt: extra mediating kernel for paradigms 2 and 3 data/ddi/ready/goldPosDomainPairs.txt: tab-delimited gold-standard positive domain instance pairs, one pair per line data/ddi/ready/goldNegDomainPairs.txt: tab-delimited gold-standard negative domain instance pairs, one pair per line data/rri/ready/residues.txt: list of residues, one residue per line, in format data/rri/ready/residueKernel.txt: residue kernel in tab-delimited format data/rri/ready/goldPosResiduePairs.txt: tab-delimited gold-standard positive residue pairs, one pair per line data/rri/ready/goldNegResiduePairs.txt: tab-delimited gold-standard negative residue instance pairs, one pair per line To analyze the results: At the base directory, run the an task "analyze": ant analyze The reported values are in the column "AUC (all)"